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ea0081rc3.2 | Rapid Communications 3: Thyroid 1 | ECE2022

Performance of a raman fingerprint in thyroid nodules with indeterminate cytology: a prospective blinded monocentric study

Palermo Andrea , Sodo Armida , Mihaela Naciu Anda , Di Gioacchino Michael , Paolucci Alessio , Di Masi Alessandra , Maggi Daria , Crucitti Pierfilippo , Longo Filippo , Perrella Eleonora , Taffon Chiara , Verri Martina , Antonietta Ricci Maria , Crescenzi Anna

Background: Molecular analysis of thyroid fine-needle aspiration biopsy (FNA) was proposed to improve indeterminate nodules management. However, sensibility and specificity as well as the cost of molecular diagnostics require to be improved to increase their cost-effectiveness for medical practice setting. Raman spectroscopy (RS) demonstrated ability in separating benign from malignant thyroid lesions in surgically removed tissues, based on specific RS profile. This study aime...